Biomedical laboratory complex

The modern biomedical laboratory complex of the Fraunhofer FEP with safety level S1 consists of laboratory units for microbiology, cell biology, bioanalytics as well as for surface chemistry and biotechnological reaction processes. This enables us to carry out interdisciplinary and industry-orientated research and development for a wide range of life science applications. We combine our technological core competences such as low-energy electron beam technology with medical-biotechnological applications. The laboratory unit fulfils all the requirements for biological safety level S2.

With our extensive laboratory and measurement technology, we offer customized solutions for various industries such as medical technology, pharmaceuticals, environmental technology and biotechnology. We combine technological expertise with practical application scenarios.

Focal points

In vitro microbiology and cell biology to elucidate complex mechanisms of action
Utilization of low-energy electron beam technology (< 300 keV) for:
- Sterilization and inactivation
- Material modification and cross-linking
- Hormetic stimulation of biotechnological processes
- Seed and wastewater treatment
Research into innovative disinfection solutions with plasma and UV technologies
Development of biocompatible materials
Integrated bioreactor systems for biotechnological processes

By combining electron beam processes and biotechnology, we are opening up new application possibilities for sustainable resource extraction, energy generation and the production of bio-based materials.

Microbiology laboratory unit

Aerobic and anaerobic cultivation of microorganisms
Assessment and detection of surface-selective contamination and degree of microbial contamination
Hygienization concepts for sterilization and disinfection using electron beam, UV and plasma technology
Proof of sterility and bioburden test
Targeted bacterial contamination with subsequent application of selective strategies for the hygienization of materials
Testing of biocidal substances, substrates and surfaces
Antimicrobial evaluation of coatings
Investigation of biofilm formation
Investigation of the effect of low-energy electron radiation on microbial activity
Investigation of factors influencing biomass productivity and product synthesis of phototrophic microorganisms

Cell biology laboratory unit

Cell cultivation of suspension cells and adherent cells (primary cells, cell lines) in mono- and co-culture
Testing the biocompatibility and biofunctionality of materials and surfaces, including selective surface treatment technologies
Cell analysis: assessment of viability, proliferation, differentiation; of changes in cell number, cell cycle and membrane potential
Evaluation of the influence of cell and tissue damage by assessing apoptosis and necrosis as well as DNA damage
Evaluation of cell adhesion: interaction of surfaces with cells
Cytotoxicity tests
Preparation and modification of biological tissue using electron beam technology
Targeted influence on cell function through the use of electron beam technology (inactivation or stimulation)

Biotechnological processes

© Fraunhofer FEP
Samples with electron beam-treated bacteria for copper leaching

Exposure of aqueous systems containing microorganisms or cells to accelerated electrons for use in recycling processes, energy generation or chemical supply and wastewater treatment or vaccine production
Monitoring of bioprocesses using sensor technology
Methods for (indirect) cell density determination
Sum parameter determination in waste water analysis
Establishment of bioreactor systems with/without integrated electron beam sources

Surface chemical processes

Electron beam-assisted surface modification guarantees the sustainable preservation of material properties, while at the same time the surface properties can be customized:

Modulation of wetting properties through surface functionalization
Improvement of material-specific adhesive properties
Selective influencing of the biocompatibility of material surfaces
Grafting processes for functional surface coating (non-stick coatings, biocidal coatings)
Cross-linking and curing of surface-selective coatings
Material-friendly surface hygienization

Biomedical laboratory complex